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1

10.1038/17969

Wittinghofer, Alfred, Vetter, Ingrid R., Nowak, Christine, Nishimoto, Takeharu, Kuhlmann, Jürgen

Journal:

Year:

1999

Language:

english

File:

PDF, 691 KB

english, 1999

2

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

Pai, Emil F., Kabsch, Wolfgang, Krengel, Ute, Holmes, Kenneth C., John, Jacob, Wittinghofer, Alfred

Journal:

Year:

1989

File:

PDF, 738 KB

1989

3

10.1038/35003249

Waldmann, Herbert, Kuhlmann, Jürgen, Bader, Benjamin, Kuhn, Karsten, Owen, David J., Wittinghofer, Alfred

Journal:

Year:

2000

Language:

english

File:

PDF, 214 KB

english, 2000

4

10.1038/35003254

Waldmann, Herbert, Kuhlmann, Jürgen, Bader, Benjamin, Kuhn, Karsten, Owen, David J., Wittinghofer, Alfred

Journal:

Year:

2000

Language:

english

File:

PDF, 275 KB

english, 2000

5

RanGAP mediates GTP hydrolysis without an arginine finger

Seewald, Michael J., Körner, Carolin, Wittinghofer, Alfred, Vetter, Ingrid R.

Journal:

Year:

2002

Language:

english

File:

PDF, 551 KB

english, 2002

6

Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras

Ahmadian, Mohammad Reza, Stege, Patricia, Scheffzek, Klaus, Wittinghofer, Alfred

Journal:

Natural Structural Biology

Year:

1997

File:

PDF, 613 KB

1997

7

The structure of the TrmE GTP-binding protein and its implications for tRNA modification

Scrima, Andrea, Vetter, Ingrid R, Armengod, M Eugenia, Wittinghofer, Alfred

Journal:

The EMBO Journal

Year:

2004

Language:

english

File:

PDF, 543 KB

english, 2004

8

Structure-Function Relationships of the G Domain, a Canonical Switch Motif

Wittinghofer, Alfred, Vetter, Ingrid R.

Journal:

Annual Review of Biochemistry

Year:

2011

Language:

english

File:

PDF, 1.11 MB

english, 2011

9

GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins

Matthias Geyer, Alfred Wittinghofer

Journal:

Current Opinion in Structural Biology

Year:

1997

Language:

english

File:

PDF, 715 KB

english, 1997

10

Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling

Zimmermann, Gunther, Papke, Björn, Ismail, Shehab, Vartak, Nachiket, Chandra, Anchal, Hoffmann, Maike, Hahn, Stephan A., Triola, Gemma, Wittinghofer, Alfred, Bastiaens, Philippe I. H., Waldmann, Herbe

Journal:

Year:

2013

Language:

english

File:

PDF, 1.15 MB

english, 2013

11

Individual Rate Constants for the Interaction of Ras Proteins with GTPase-Activating Proteins Determined by Fluorescence Spectroscopy

Ahmadian, Mohammad Reza, Hoffmann, Ulrike, Goody, Roger S., Wittinghofer, Alfred

Journal:

Year:

1997

Language:

english

File:

PDF, 126 KB

english, 1997

12

Selective Targeting of the KRAS G12C Mutant: Kicking KRAS When It’s Down

Hobbs, G. Aaron, Wittinghofer, Alfred, Der, Channing J.

Journal:

Year:

2016

Language:

english

File:

PDF, 536 KB

english, 2016

13

Characterization of a novel RP2–OSTF1 interaction and its implication for actin remodelling

Lyraki, Rodanthi, Lokaj, Mandy, Soares, Dinesh C., Little, Abigail, Vermeren, Matthieu, Marsh, Joseph A., Wittinghofer, Alfred, Hurd, Toby

Journal:

Journal of Cell Science

Year:

2018

Language:

english

File:

PDF, 6.02 MB

english, 2018

14

Pierre Chardin, un pionnier de laÂ dÃ©couverte desÂ gÃ¨nes et protÃ©ines de laÂ superfamille Ras

Barelli, HÃ©lÃ¨ne, Camonis, Jacques, de Gunzburg, Jean, Goud, Bruno, Moreau-Gachelin, FranÃ§oise, Wittinghofer, Alfred, Zahraoui, Ahmed

Journal:

Year:

2020

File:

PDF, 11.21 MB

2020

15

Crystallization and preliminary X-ray crystallographic study of the Ras-GTPase-activating domain of human p120GAP

Klaus Scheffzek, Alfred Lautwein, Anna Scherer, Sybille Franken, Alfred Wittinghofer

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1997

Language:

english

File:

PDF, 91 KB

english, 1997

16

Chemoenzymatic Synthesis of Biotinylated Ras Peptides and Their Use in Membrane Binding Studies of Lipidated Model Proteins by Surface Plasmon Resonance

Michael Schelhaas, Edgar Nägele, Norman Kuder, Benjamin Bader, Jürgen Kuhlmann, Alfred Wittinghofer, Herbert Waldmann

Journal:

Chemistry - A European Journal

Year:

1999

Language:

english

File:

PDF, 293 KB

english, 1999

17

Ras-Mediated Cleavage of a GTP Analogue by a Novel Mechanism

Robert Gail, Burkhard Costisella, M. Reza Ahmadian, Alfred Wittinghofer

Journal:

Year:

2001

Language:

english

File:

PDF, 106 KB

english, 2001

18

Titelbild

Alfred Wittinghofer, Herbert Waldmann

Journal:

Angewandte Chemie

Year:

2000

File:

PDF, 18 KB

2000

19

Ras – ein molekularer Schalter bei der Tumorentstehung

Alfred Wittinghofer, Herbert Waldmann

Journal:

Angewandte Chemie

Year:

2000

Language:

german

File:

PDF, 472 KB

german, 2000

20

Ras—A Molecular Switch Involved in Tumor Formation

Alfred Wittinghofer, Herbert Waldmann

Journal:

Angewandte Chemie International Edition

Year:

2000

Language:

english

File:

PDF, 491 KB

english, 2000

21

Cover Picture

Alfred Wittinghofer, Herbert Waldmann

Journal:

Angewandte Chemie International Edition

Year:

2000

File:

PDF, 17 KB

2000

22

Chemoenzymatische Synthese fluoreszierender N-Ras-Lipopeptide und ihre Verwendung bei In-vivo-Studien zur Membranlokalisierung

Prof. Dr. Herbert Waldmann, Dr. Michael Schelhaas, Dr. Edgar Nügele, Dr. Jürgen Kuhlmann, Prof. Dr. Alfred Wittinghofer, Hans Schroeder, Prof. John R. Silvius

Journal:

Angewandte Chemie

Year:

1997

File:

PDF, 604 KB

1997

23

Lipidierte Ras- und Rab-Peptide und -Proteine: Synthese, Struktur und Funktion

Luc Brunsveld, Jürgen Kuhlmann, Kirill Alexandrov, Alfred Wittinghofer, Roger S. Goody, Herbert Waldmann

Journal:

Angewandte Chemie

Year:

2006

Language:

german

File:

PDF, 1.73 MB

german, 2006

24

Stabilisierung eines niederaffinen Zustands für Effektoren im menschlichen Ras-Protein durch Cyclenkomplexe

Ina C. Rosnizeck, Thorsten Graf, Michael Spoerner, Jens Tränkle, Daniel Filchtinski, Christian Herrmann, Lothar Gremer, Ingrid R. Vetter, Alfred Wittinghofer, Burkhard König, Hans Robert Kalbitzer

Journal:

Angewandte Chemie

Year:

2010

Language:

german

File:

PDF, 635 KB

german, 2010

25

Synthesis of the Rheb and K-Ras4B GTPases

Yong-Xiang Chen, Sebastian Koch, Katharina Uhlenbrock, Katrin Weise, Debapratim Das, Lothar Gremer, Luc Brunsveld, Alfred Wittinghofer, Roland Winter, Gemma Triola, Herbert Waldmann

Journal:

Angewandte Chemie

Year:

2010

Language:

english

File:

PDF, 859 KB

english, 2010

26

Chemoenzymatic Synthesis of Fluorescent N-Ras Lipopeptides and Their Use in Membrane Localization Studies in Vivo

Prof. Dr. Herbert Waldmann, Dr. Michael Schelhaas, Dr. Edgar Nägele, Dr. Jürgen Kuhlmann, Prof. Dr. Alfred Wittinghofer, Hans Schroeder, Prof. John R. Silvius

Journal:

Angewandte Chemie International Edition

Year:

1997

Language:

english

File:

PDF, 785 KB

english, 1997

27

Lipidated Ras and Rab Peptides and Proteins—Synthesis, Structure, and Function

Luc Brunsveld, Jürgen Kuhlmann, Kirill Alexandrov, Alfred Wittinghofer, Roger S. Goody, Herbert Waldmann

Journal:

Angewandte Chemie International Edition

Year:

2006

Language:

english

File:

PDF, 1.81 MB

english, 2006

28

Stabilizing a Weak Binding State for Effectors in the Human Ras Protein by Cyclen Complexes

Ina C. Rosnizeck, Thorsten Graf, Michael Spoerner, Jens Tränkle, Daniel Filchtinski, Christian Herrmann, Lothar Gremer, Ingrid R. Vetter, Alfred Wittinghofer, Burkhard König, Hans Robert Kalbitzer

Journal:

Angewandte Chemie International Edition

Year:

2010

Language:

english

File:

PDF, 649 KB

english, 2010

29

Synthesis of the Rheb and K-Ras4B GTPases

Yong-Xiang Chen, Sebastian Koch, Katharina Uhlenbrock, Katrin Weise, Debapratim Das, Lothar Gremer, Luc Brunsveld, Alfred Wittinghofer, Roland Winter, Gemma Triola, Herbert Waldmann

Journal:

Angewandte Chemie International Edition

Year:

2010

Language:

english

File:

PDF, 895 KB

english, 2010

30

The unique plant RhoGAPs are dimeric and contain a CRIB motif required for affinity and specificity towards cognate small G proteins

Antje Schaefer, Kathrin Höhner, Antje Berken, Alfred Wittinghofer

Journal:

Year:

2011

Language:

english

File:

PDF, 2.73 MB

english, 2011

31

Nachrichten des Verbandes Biologie, Biowissenschaften & Biomedizin in Deutschland

Alfred Wittinghofer

Journal:

Biologie in unserer Zeit

Year:

2008

Language:

german

File:

PDF, 269 KB

german, 2008

32

Synthesis of GTP-Derived Ras Ligands

Laurent Soulère, Courtney Aldrich, Oliver Daumke, Robert Gail, Lars Kissau, Alfred Wittinghofer, Herbert Waldmann

Journal:

Year:

2004

Language:

english

File:

PDF, 218 KB

english, 2004

33

ChemInform Abstract: New N-2-Labelled Fluorescent Derivatives of Guanosine Nucleotides and Their Interaction with GTP-Binding Proteins.

Nils Ostermann, Mohammad Reza Ahmadian, Alfred Wittinghofer, R. S. Goody

Journal:

Year:

1999

File:

PDF, 30 KB

1999

34

ChemInform Abstract: Ras — A Molecular Switch Involved in Tumor Formation.

Alfred Wittinghofer, Herbert Waldmann

Journal:

Year:

2001

File:

PDF, 24 KB

2001

35

ChemInform Abstract: Synthesis of Functional Ras Lipoproteins and Fluorescent Derivatives.

Karsten Kuhn, David J. Owen, Benjamin Bader, Alfred Wittinghofer, Juergen Kuhlmann, Herbert Waldmann

Journal:

Year:

2001

File:

PDF, 23 KB

2001

36

T cell epitopes encompassing the mutational hot spot position 61 of p21 ras. Promiscuity in ras peptide binding to HLA

Tobias Gedde-Dahl Iii, Anne Spurkland, Beate Fossum, Erik Thorsby, Gustav Gaudernack, Alfred Wittinghofer

Journal:

European Journal of Immunology

Year:

1994

Language:

english

File:

PDF, 461 KB

english, 1994

37

Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders

Lothar Gremer, Torsten Merbitz-Zahradnik, Radovan Dvorsky, Ion C. Cirstea, Christian Peter Kratz, Martin Zenker, Alfred Wittinghofer, Mohammad Reza Ahmadian

Journal:

Year:

2011

Language:

english

File:

PDF, 600 KB

english, 2011

38

Synthese der Schafinsulin-A-Kette mit 6–11-Disulfidring, I

Alfred Wittinghofer

Journal:

European Journal of Organic Chemistry

Year:

1974

File:

PDF, 909 KB

1974

39

Structure and function of Rho-type molecular switches in plants

Antje Berken, Alfred Wittinghofer

Journal:

Plant Physiology and Biochemistry

Year:

2008

Language:

english

File:

PDF, 1.52 MB

english, 2008

40

Crystal structure of THEP1 from the hyperthermophileAquifex aeolicus: a variation of the RecA fold

Michael Roßbach, Oliver Daumke, Claudia Klinger, Alfred Wittinghofer, Michael Kaufmann

Journal:

BMC Structural Biology

Year:

2005

Language:

english

File:

PDF, 3.18 MB

english, 2005

41

Intracellular distribution of β-catenin in colorectal adenomas, carcinomas and Peutz-Jeghers polyps

Peter Herter, Cornelius Kuhnen, Klaus-Michael Müller, Alfred Wittinghofer, Oliver Müller

Journal:

Journal of Cancer Research and Clinical Oncology

Year:

1999

Language:

english

File:

PDF, 455 KB

english, 1999

42

Interactions between Ras proteins and their effectors

Frank McCormick, Alfred Wittinghofer

Journal:

Current Opinion in Biotechnology

Year:

1996

Language:

english

File:

PDF, 807 KB

english, 1996

43

RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange

Elif Yaman, Raphael Gasper, Carolin Koerner, Alfred Wittinghofer, Uygar H. Tazebay

Journal:

Year:

2009

Language:

english

File:

PDF, 660 KB

english, 2009

44

10.1038/24884

Bos, Johannes L., de Rooij, Johan, Zwartkruis, Fried J. T., Verheijen, Mark H. G., Cool, Robbert H., Nijman, Sebastian M. B., Wittinghofer, Alfred

Journal:

Year:

1998

Language:

english

File:

PDF, 489 KB

english, 1998

45

10.1038/32204

Wittinghofer, Alfred, Renault, Louis, Nassar, Nicolas, Vetter, Ingrid, Becker, Jörg, Klebe, Christian, Roth, Michel

Journal:

Year:

1998

Language:

english

File:

PDF, 758 KB

english, 1998

46

Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis

Schlichting, Ilme, Almo, Steven C., Rapp, Gert, Wilson, Keith, Petratos, Kyriakos, Lentfer, Arno, Wittinghofer, Alfred, Kabsch, Wolfgang, Pai, Emil F., Petsko, Gregory A.

Journal:

Year:

1990

File:

PDF, 948 KB

1990

47

Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins

Prakash, Balaji, Praefcke, Gerrit J. K., Renault, Louis, Wittinghofer, Alfred, Herrmann, Christian

Journal:

Year:

2000

Language:

english

File:

PDF, 528 KB

english, 2000

48

Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form

Scheffzek, Klaus, Klebe, Christian, Fritz-Wolf, Karin, Kabsch, Wolfgang, Wittinghofer, Alfred

Journal:

Year:

1995

File:

PDF, 533 KB

1995

49

The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with RaplA and a GTP analogue

Nassar, Nicolas, Horn, Gudrun, Herrmann, Christian A., Scherer, Anna, McCormick, Frank, Wittinghofer, Alfred

Journal:

Year:

1995

File:

PDF, 1001 KB

1995

50

Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras

Scheffzek, Klaus, Lautwein, Alfred, Kabsch, Wolfgang, Reza Ahmadian, Mohammad, Wittinghofer, Alfred

Journal:

Year:

1996

File:

PDF, 2.06 MB

1996